Genetic susceptibility to scrapie in sheep: A clinically relevant theme in veterinary medical education

Ryan, M. T. and Sweeney, T. (2005) Genetic susceptibility to scrapie in sheep: A clinically relevant theme in veterinary medical education. Journal of Veterinary Medical Education, 32 (4). pp. 544-550. ISSN 0748321X (ISSN)

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Abstract

Rationale for this study - This article describes and evaluates two molecular biology practical classes based around the theme of genetic susceptibility to scrapie in sheep. These practical classes allow students to experience a range of molecular biology techniques in the context of a clinically based genetic disease. Methodology - The two molecular biology practical classes described are evaluated in terms of their perceived usefulness to study by first-year veterinary medicine students. The students' ratings are then assessed in relation to the approaches to studying (i.e., deep, strategic, and surface). These dimensions of learning are measured using the 52-item Approaches to Studying Inventory (ASI). Results - The overall ratings from students in relation to both the practical classes were found to be positive. The scrapie genotyping practical was the highest-ranking laboratory-based practical in the first-year curriculum. Ratings in terms of usefulness to studies for both practical classes were found to be significantly higher for students with higher deep learning scores. Conclusion - The practical classes described here provide a clinically relevant scenario within which molecular biology concepts and methods can be illustrated to veterinary students. The positive correlation with deep learning is more evident for the scrapie genotyping practical than for the DNA extraction practical. This may reflects the complexity of the former, which is greater both technically and conceptually. © 2005 AAVMC.

Item Type: Article
Additional Information: Cited By :3; Export Date: 23 February 2015; Correspondence Address: Ryan, M.T.; College of Life Sciences, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland; email: marion.ryan@ucd.ie; References: (2005), www.vetgen.com, VetGen home page VetGen, Ann Arbor, MI(2005) Quality Diagnostic Laboratory Services, , www.vita-tech.com, Vita-Tech, Markham, ON; (2005), http://www.ucd.ie/vetmed, Faculty home page. University College Dublin, IrelandBelt, B.G.M., Muileman, I.H., Schreuder, B.E.C., Bos-De Ruijter, J., Gielkens, A.L.K., Smits, M.A., Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie (1995) J Gen Vir, 76, pp. 509-517; Hunter, N., Moore, L., Hosie, B.D., Dingwall, W.S., Greig, A., Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland (1997) Vet Rec, 140, pp. 59-63; Hunter, N., Goldmann, W., Foster, J.D., Cairns, D., Smith, G., Natural scrapie and PrP genotype: Case-control studies in British sheep (1997) Vet Rec, 141, pp. 137-140; Laplanche, J.L., Chatelain, J., Westaway, D., Thomas, S., Dussaucy, M., Brugere-Picoux, J., Launay, J.M., PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis (1993) Genomics, 15, pp. 30-37; Laplanche, J.L., Chatelain, J., Beaudry, P., Dussaucy, M., Bonneau, C., Launay, J.M., French autochthonous scrapied sheep without the 136Val PrP polymorphism (1993) Mamm Genome, 4, pp. 463-464; Westaway, D., Zuliain, V., Cooper, C.M., Da Costa, M., Newman, S., Jenny, A.L., Detwilar, L., Prusiner, S.B., Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie (1994) Gene Dev, 8, pp. 959-969; Hunter, N., Foster, J.D., Goldmann, W., Stear, M.J., Hope, J., Bostock, C., Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes (1996) Arch Virol, 141, pp. 809-824; Tranulis, M.A., Osland, A., Bratberg, B., Ulvund, M.J., Prion protein gene polymorphisms in sheep with natural scrapie and healthy controls in Norway (1999) J Gen Vir, 80, pp. 1073-1077; Thorgeirsdottir, S., Sigurdarson, S., Thorisson, H.M., Georgsson, G., Palsdottir, A., PrP gene polymorphism and natural scrapie in Icelandic sheep (1999) J Gen Vir, 80, pp. 2527-2534; Elsen, J.-M., Amigues, Y., Schelcher, F., Ducrocq, V., An-Dreoletti, O., Eychenne, F., Tien Khang, J.V., Laplanche, J.-L., Genetic susceptibility and transmission factors in scrapie: Detailed analysis of an epidemic in a closed flock of Romanov (1996) Arch Virol, 144, pp. 431-445; O'Doherty, E., Healy, A., Aherne, M., Hanrahan, J.P., Weavers, E., Doherty, M., Roche, J.F., Sweeney, T., Prior protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland (2002) Res Vet Sci, 73, pp. 243-250; O'Doherty, E., Healy, A., Aherne, M., Hanrahan, J.P., Weavers, E., Doherty, M., Roche, J.F., Sweeney, T., Prion protein gene polymorphisms in pedigree sheep in Ireland (2001) Res Vet Sci, 70, pp. 51-56; http://www.mjr.com/, MJResearch home page(2005) Pyrosequencing: Genetic Analysis for Clinical Research, , www.pyrosequencing.com, Biotage, Uppsala, Sweden; (2005), www.appliedbiosystems.com, Applied Biosystems home page. Applied Biosystems, Foster City, CA(2005), www.cambrex.com, Cambrex home page. Cambrex Corporation, East Rutherford, NJRyan, M.T., Mulholland, C.W., Gilmore, W.S., Applications of computer-aided learning in biomedical sciences: Considerations in design and evaluation (2000) Brit J Biomed Sci, 57, pp. 28-34; Entwistle, N., Tait, H., McCune, V., Patterns of response to Approaches to Studying Inventory across contrasting groups and contexts (2000) Eur J Psychol Educ, 15, pp. 33-48; Entwistle, N., Tait, H., Approaches to learning, evaluations of teaching, and preferences for contrasting academic environments (1990) High Educ, 19, pp. 169-194; Tait, H., Entwhistle, N., McCune, V., ASSIST: A reconceptualisation of the Approaches to Study Inventory (1998) Improving Student Learning: Improving Students As Learners, pp. 262-271. , Rust C, ed. Oxford: Oxford Centre for Staff and Learning Development, Oxford Brookes University; Ryan, M.T., Irwin, J.A., Bannon, F.J., Mulholland, C.W., Baird, A.W., Observations of veterinary medicine students' approaches to study in pre-clinical years (2004) J Vet Med Educ, 31, pp. 242-254
Uncontrolled Keywords: animal; curriculum; education; genetic predisposition; genetics; health care quality; human; medical education; medical student; molecular biology; psychological aspect; review; scrapie; sheep; Animals; Education, Medical, Undergraduate; Education, Veterinary; Educational Measurement; Genetic Predisposition to Disease; Humans; Program Evaluation; Students, Medical; Ovis aries
Depositing User: National Forum
Date Deposited: 10 Dec 2015 22:25
Last Modified: 10 Dec 2015 22:29
URI: http://eprints.teachingandlearning.ie/id/eprint/3644

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